The disease and identification.
The disease due to leptospirosis is normaly known as Weils disease and also known as spirochaetosis, icterus gravis, etc in various parts of the world. In kerala, in Malayalam it is known as ELIPANI(rat fever) not rat bite fever. It is a sudden febrile animal borne infection charecterised in human beings by fever , icterus, albumen in urine,bleedings , severe headache and pain in the body, skin rashes, enlargement of liver, prostration and passing of bile in urine and faeces and loose motions and abdominal pains and continiues with irregular fever which starts from 4 th day onwards and lasts for a week or upto 10 days after that fever comes down and after 14 the day the healing starts.
The disease due to leptospirosis is normaly known as Weils disease and also known as spirochaetosis, icterus gravis, etc in various parts of the world. In kerala, in Malayalam it is known as ELIPANI(rat fever) not rat bite fever. It is a sudden febrile animal borne infection charecterised in human beings by fever , icterus, albumen in urine,bleedings , severe headache and pain in the body, skin rashes, enlargement of liver, prostration and passing of bile in urine and faeces and loose motions and abdominal pains and continiues with irregular fever which starts from 4 th day onwards and lasts for a week or upto 10 days after that fever comes down and after 14 the day the healing starts.
Causal organism.
Leprospira icterohaemorrhagiae is the organism. It is a slender, closely wound, very actively motile spirochaeta varying in length from 1m to 4m. The spirals are shallow and regular , each half m in length, thin and acutely bent as a crook. It is found in the blood, urine, ceribrospinal fluid and sputum of the patient. They can be demonstrated by a dark ground illustration by the day in the urine.It can be cultivated on Naguchi's medium or in a mixture of peptone. Besides these types of Europeon strains,there are fifty named strains of Leptospira with varying invasive potentialities.
Source and reservoir of infection.
The natural reservoir of infection are the rats and the field mice. These rodents are tolerent to the spirochaeta and not suffer from the disease. The organism is excreted in their urine and faeces,The disease also occur in dogs but the sudden source of infection to man is through the soil contaminated with infective excereta, specially urine.
The incubation period and period of infectivity.
The normal incubation period is one week with a range of six to eight days rarely and may go upto 13 days. Route and mode of transmission to man is through microscopic abrasions occured during work in soil,drains.sewers, etc. Bathing in contaminated water has a given rise to outbreaks. It may occur among farmers, sewer workers,miners,fishmongers and other workers during out breaks. Urine of the patient can be infective from the end of first week onwards from 10 to 25 th day, may extend upto 2 months. Rats are infective during their life. Man possess no natural immunity. Aquired immunity is not solid or remains for long time. The disease occure as severe or mild attack depending upon the type of infecting organism.
Geographical prevalence of the disease.
The disease is virulent in warm countries. The disease was early thought to be prevalent in Japan. It is endemic in Holond, Congo, coastal Germany, Africa, Sudan, Indonenesia, Malayasia and other countries.
PREVENTION AND CONTROL.
Source and reservoir of infection.
The natural reservoir of infection are the rats and the field mice. These rodents are tolerent to the spirochaeta and not suffer from the disease. The organism is excreted in their urine and faeces,The disease also occur in dogs but the sudden source of infection to man is through the soil contaminated with infective excereta, specially urine.
The incubation period and period of infectivity.
The normal incubation period is one week with a range of six to eight days rarely and may go upto 13 days. Route and mode of transmission to man is through microscopic abrasions occured during work in soil,drains.sewers, etc. Bathing in contaminated water has a given rise to outbreaks. It may occur among farmers, sewer workers,miners,fishmongers and other workers during out breaks. Urine of the patient can be infective from the end of first week onwards from 10 to 25 th day, may extend upto 2 months. Rats are infective during their life. Man possess no natural immunity. Aquired immunity is not solid or remains for long time. The disease occure as severe or mild attack depending upon the type of infecting organism.
Geographical prevalence of the disease.
The disease is virulent in warm countries. The disease was early thought to be prevalent in Japan. It is endemic in Holond, Congo, coastal Germany, Africa, Sudan, Indonenesia, Malayasia and other countries.
PREVENTION AND CONTROL.
Rat control in vulnarable areas like coastal side and sorrounding areas,sewers in towns and urban areas, etc. Protective clothing for workers, in vulnerable trades like sewer workers and divers,etc. Swimming in infected pools should be avoided. Attendants in hospital should wear protective clothing. Disinfection of items used by patient including urine,faeces, etc, and terminal disinfection also carried out. Naguchi prepared a vaccine for giving to persons enggaged in hazardous professions.